1423136-80-4

Upstream product

• 131786-00-0 (4-Chloro-phenyl)-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-acetic acid methyl ester 
• 3623-15-2 phenyl propargyl ketone 
• 43189-20-4 methyl (±)-2-amino-2-(4-chlorophenyl)acetate 
• 555-16-8 4-nitrobenzaldehdye 

Relevant academic research and scientific papers

Cu(OAc)2/FOXAP complex catalyzed construction of 2,5-dihydropyrrole derivatives via asymmetric 1,3-dipolar cycloaddition of azomethine ylides to ethynyl ketones

Catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides to ethynyl ketones catalyzed by the Cu(OAc)2/FOXAP (ferrocenyl oxazolinylphosphine) complex was developed, affording 2,5-dihydropyrrole derivatives in good to excellent yields (up to 99%) and excellent levels of enantioselectivities (up to 98% ee). This highly efficient chiral N,P-ligand/Cu(OAc)2 catalytic system was also applicable for the 1,3-dipolar cycloaddition of α-arylglycine ester-generated azomethine ylides to ynones, affording exclusive quaternary carbon-containing cis-2,5-dihydropyrroles in excellent enantioselectivities (89-92% ee).

Enantioselective construction of 2,5-dihydropyrrole skeleton with quaternary stereogenic center via catalytic asymmetric 1,3-dipolar cycloaddition involving α-arylglycine esters

A catalytic asymmetric construction of synthetically and biologically important 2,5-dihydropyrrole scaffolds with concomitant creation of multiple chiral carbon centers including one quaternary stereogenic center in high yields (up to 99%) and excellent e