1423172-04-6Relevant articles and documents
Synthesis of N4-(substituted phenyl)-N4-alkyl/ desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells
Gangjee, Aleem,Zaware, Nilesh,Devambatla, Ravi Kumar Vyas,Raghavan, Sudhir,Westbrook, Cara D.,Dybdal-Hargreaves, Nicholas F.,Hamel, Ernest,Mooberry, Susan L.
, p. 891 - 902 (2013/03/14)
A series of fourteen N4-(substituted phenyl)-N 4-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines was synthesized as potential microtubule targeting agents. The synthesis involved a Fisher indole cyclization of 2-amino-6-hydrazin