1423218-80-7

Basic information

• Product Name: C₁₉H₂₄N₂O₆S
• CAS NO: 1423218-80-7
• Molecular Weight: 408.475
• Mol File: 1423218-80-7.mol

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₄N₂O₆S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₄N₂O₆S(1423218-80-7)
• EPA Substance Registry System: C₁₉H₂₄N₂O₆S(1423218-80-7)

Safety Data

• Hazardous Substances Data: 1423218-80-7(Hazardous Substances Data)

Upstream product

• 20469-63-0 1-iodo-2,4-dimethoxybenzene 
• 1384331-68-3 (S)-mehyl 3-mehyl-2-(pyridine-2-sulfonamido)butanoate 
• 6306-52-1 L-valine methylester hydrochloride 
• 66715-65-9 pyridine-2-sulfonyl chloride 

Relevant articles and documents

Palladium-catalyzed N-(2-pyridyl)sulfonyl-directed C(sp3)-H γ-arylation of amino acid derivatives

The direct Pd-catalyzed γ-arylation of amino acid esters bearing a removable N-(2-pyridyl)sulfonyl directing group is described. A variety of N-(2-pyridyl)sulfonamide amino acid derivatives, including α-quaternary amino acid and β-amino acid substrates, react with iodoarenes in the presence of Pd(OAc)2 to provide γ-arylated products in synthetically useful yields. An unprecedented remote C(sp3)-H arylation of dipeptides is presented, illustrating the compatibility of the method with the presence of the peptidic bond. The process occurs without racemization at the Cα center and the auxiliary controlling group can be easily installed and removed in the amino acid backbone. A bimetallic Pd II γ-metalated complex has been isolated and characterized showing the key role exerted by the (2-pyridyl)sulfonyl unit.