142325-64-2Relevant academic research and scientific papers
A Highly Convergent Total Synthesis of Norhalichondrin B
Das, Dipendu,Nicolaou, K. C.,Pan, Saiyong,Rigol, Stephan,Shelke, Yogesh,Ye, Qiuji
, p. 20970 - 20979 (2021/12/14)
A new synthetic strategy for the total synthesis of norhalichondrin B featuring a highly convergent approach and our recently disclosed reverse approach for the synthesis of cyclic ether structural motifs is disclosed. Resulting in the shortest route to norhalichondrin B disclosed thus far, the reported total synthesis was achieved through the synthesis of two almost equally complex fragments whose coupling and short elaboration sequence featured an essential epimerization of the C16 stereocenter occurring concurrently with a simple acid-induced deprotection, a tactic based on a prior study along the synthetic route. This unprecedented strategy within the halichondrin family of natural products could find practical application to the synthesis of other more or less complex natural or designed halichondrin analogues.
Synthetic Studies towards Halichondrins: Synthesis of the C.27-C.38 Segment
Aicher, Thomas D.,Buszek, Keith R.,Fang, Francis G.,Forsyth, Craig J.,Jung, Sun Ho,et al.
, p. 1549 - 1552 (2007/10/02)
An efficient synthesis of the C.27-C.38 segment of halichondrins is accomplished, using the Ireland-Claisen rearrangement, Ni(II)/Cr(II)-mediated coupling and Michael reactions as the key steps.
