142335-79-3Relevant academic research and scientific papers
Cyclohepta[b]pyran derivatives with platelet antiaggregating and other activities
Bargagna,Longobardi,Mariani,Schenone,Rossi,D'Amico,Falzarano
, p. 345 - 355 (2007/10/02)
The synthesis of some N,N-disubstituted 4-amino-6,7,8,9-tetrahydro-3- phenylcyclohepta[b]pyran-2(5H)-ones by reaction of phenylchloroketene with a series of N,N-disubstituted 2-aminomethylenecycloheptanones, followed by dehydrochlorination of the primary adducts with DBN, is described. Some compounds showed a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as weak local anesthetic, antiinflammatory and analgesic activities in mice and rats.
