142341-04-6

Basic information

• Product Name: Propanoic acid, 2,2-dimethyl-, [[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]ethoxyphosphinyl]oxy]methyl ester
• Synonyms: Propanoic acid, 2,2-dimethyl-, [[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]ethoxyphosphinyl]oxy]methyl ester;2,2-Dimethylpropanoic acid [[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]ethoxyphosphinyl]oxy]methyl ester;Mono(pivaloyloxyMethyl) Ethyl Adefovir;Mono-POM Ethyl Adefovir;Adefovir Dipivoxyl IMpurity C;((((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)-(ethoxy)phosphoryl)oxy)methyl pivalate;Propanoic acid, 2,2-dimethyl-, [[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]ethoxyphosphinyl]oxy]methy;Adefovir Dipivoxil Impurity C
• CAS NO: 142341-04-6
• Molecular Formula: C16H26N5O6P
• Molecular Weight: 415
• Product Categories: Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
• Mol File: 142341-04-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 586.4°C at 760 mmHg
• Flash Point: 308.4°C
• Appearance: /
• Density: 1.39
• Vapor Pressure: 9.87E-14mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Stability: Moisture Sensitive
• CAS DataBase Reference: Propanoic acid, 2,2-dimethyl-, [[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]ethoxyphosphinyl]oxy]methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2,2-dimethyl-, [[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]ethoxyphosphinyl]oxy]methyl ester(142341-04-6)
• EPA Substance Registry System: Propanoic acid, 2,2-dimethyl-, [[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]ethoxyphosphinyl]oxy]methyl ester(142341-04-6)

Safety Data

• Hazardous Substances Data: 142341-04-6(Hazardous Substances Data)

Usage

Uses

An analogue of the antiviral drug Adefovir (A247500) with a mono-POM ester protecting group.

InChI:InChI=1/C16H26N5O6P/c1-5-26-28(23,27-10-25-15(22)16(2,3)4)11-24-7-6-21-9-20-12-13(17)18-8-19-14(12)21/h8-9H,5-7,10-11H2,1-4H3,(H2,17,18,19)

Upstream product

• 64-17-5 ethanol 
• 142341-05-7 9-<2-(phosphonomethoxy)ethyl>adenine, mono(pivaloyloxy)methyl ester 
• 142341-38-6 C₈H₁₀Cl₂N₅O₂P 
• 116384-53-3 [[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester 
• 106941-25-7 Adefovir 
• 18997-19-8 Chloromethyl pivalate 

Relevant articles and documents

Preparation method of adefovir dipivoxil impurities

The invention relates to a brand-new synthetic method of three adefovir dipivoxil impurities. The synthetic method is of great significance for synthesis of high-quality adefovir dipivoxil. The invention mainly studies synthesis of adefovir dipivoxil methyl ester impurity [[2-(6-amino-9H-purine-9-yl)-ethoxy]methyl]phosphonic acid (pivaloyloxymethyl)(methyl)ester (III), adefovir dipivoxil ethyl ester impurity [[2-(6-amino-9H-purine-9-yl)-ethoxy]methyl]phosphonic acid (pivaloyloxymethyl)(ethyl)ester (IV), adefovir dipivoxil amide impurity [[2-(6-pivaloylamido-9H-purine-9-yl)-ethoxy]methyl]phosphonic acid bi(pivaloyloxymethyl)ester (V). The specific synthetic route of the impurities is as shown in the specification.