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142342-74-3

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142342-74-3 Usage

General Description

(R)-3-Aminovalericacidethylester, also known as (R)-3-Aminovaleric acid ethyl ester, is a chemical compound with the molecular formula C6H13NO2. It is the ethyl ester of (R)-3-aminopentanoic acid and is commonly used in the synthesis of pharmaceuticals and other organic compounds. (R)-3-Aminovalericacidethylester is a chiral molecule, meaning it has a non-superimposable mirror image, and the (R) enantiomer is the specific isomer being referred to in the name. (R)-3-Aminovalericacidethylester has a variety of potential applications in the fields of medicine, organic chemistry, and materials science, and is of interest to researchers and industry professionals.

Check Digit Verification of cas no

The CAS Registry Mumber 142342-74-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,3,4 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 142342-74:
(8*1)+(7*4)+(6*2)+(5*3)+(4*4)+(3*2)+(2*7)+(1*4)=103
103 % 10 = 3
So 142342-74-3 is a valid CAS Registry Number.

142342-74-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 3-aminopentanoate

1.2 Other means of identification

Product number -
Other names Pentanoic acid,3-amino-,ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:142342-74-3 SDS

142342-74-3Relevant articles and documents

Improving Catalytic Activity and Reversing Enantio-Specificity of ω-Transaminase by Semi-Rational Engineering en Route to Chiral Bulky β-Amino Esters

Wang, Yingang,Feng, Jinhui,Dong, Wenyue,Chen, Xi,Yao, Peiyuan,Wu, Qiaqing,Zhu, Dunming

, p. 3396 - 3400 (2021/06/21)

The application of wild-type ω-transaminase was limited by steric hindrance towards bulky substrates, therefore improvement of the catalytic efficiency and stereoselectivity toward substrates with two bulky substituent adjacent to the carbonyl is of general interest. In this study, according to the double substrate binding pocket theory, a (S)-selective ω-transaminase from the Burkholderia vietnamiensis G4, which showed puny catalytic activity toward the β-keto esters with small steric hindrance, was engineered to accept bulky β-keto esters, which were not accessible by any wild-type enzyme. A few desired variants were obtained that exhibited activity toward bulky β-keto esters. Furthermore, a substrate-dependent shift in enantio-preference of HBV variant towards β-keto esters with linear or branched aliphatic substituents was observed. The best variant was applied to the asymmetric synthesis of aliphatic β-amino acids at semi-preparative scale with high yield and enantioselectivity. This study will improve the general understanding and inspire further engineering work for reversing enantio-specificity of ω-transaminases.

Stereoselective ring opening of chiral oxazolidines by reformatsky reagents: An enantioselective entry to β-amino esters

Andres, Celia,Gonzalez, Alfonso,Pedrosa, Rafael,Perez-Encabo, Alfonso

, p. 2895 - 2898 (2007/10/02)

Chiral oxazolidines obtained by condensation of aldehydes with (-).(R)- or (+).(S)-N-benzylphenylglycinol react with the Reformatsky reagent derived from ethyl bromoacetate, in mild reaction conditions (Et2O or CH2Cl2, 0°C, 15-60 min), leading to ethyl β-amino carboxylates in moderate to good diastereomeric excess (60-92%). These ring opening products are transformed into primary β-aminoesters, in one step, by debenzylation with H2/Pd on carbon without loss of their stereochemical integrity. In this way, ethyl β-amino carboxylates can be obtained in both enantiomeric forms, with chemical yields ranging 55-76% and moderate to good e.e. (60-92%).

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