142355-81-5

Basic information

• Product Name: 1-BOC-4-(4-BROMO-BUTYL)-PIPERIDINE
• Synonyms: 1-Piperidinecarboxylic acid, 4-(4-bromobutyl)-, 1,1-dimethylethyl ester
• CAS NO: 142355-81-5
• Molecular Formula: C₁₄H₂₆BrNO₂
• Molecular Weight: 320.28
• Mol File: 142355-81-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 364.947 °C at 760 mmHg
• Flash Point: 174.514 °C
• Appearance: /
• Density: 1.193 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-BOC-4-(4-BROMO-BUTYL)-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-(4-BROMO-BUTYL)-PIPERIDINE(142355-81-5)
• EPA Substance Registry System: 1-BOC-4-(4-BROMO-BUTYL)-PIPERIDINE(142355-81-5)

Safety Data

• Hazardous Substances Data: 142355-81-5(Hazardous Substances Data)

Usage

General Description

1-BOC-4-(4-BROMO-BUTYL)-PIPERIDINE is a chemical compound with the molecular formula C14H27BrN2O2. It is a derivative of piperidine with a BOC (tert-butyloxycarbonyl) protective group at the 1-position and a 4-bromo-butyl substituent. 1-BOC-4-(4-BROMO-BUTYL)-PIPERIDINE has potential applications in organic synthesis and medicinal chemistry, particularly in the development of new pharmaceuticals. It may also be used as a building block for the synthesis of more complex molecules. 1-BOC-4-(4-BROMO-BUTYL)-PIPERIDINE should be handled and used in accordance with appropriate safety measures, as it may be hazardous if not handled properly.

InChI:InChI=1/C14H26BrNO2/c1-14(2,3)18-13(17)16-10-7-12(8-11-16)6-4-5-9-15/h12H,4-11H2,1-3H3

Upstream product

• 57614-92-3 4-(piperidin-4-yl)butan-1-ol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 199538-93-7 tert-butyl 4-{4-[(methylsulfonyl)oxy]butyl}piperidine-1-carboxylate 
• 51052-78-9 4-piperidinylacetic acid 
• 142355-82-6 methyl 4-piperidin-4-yl>butanoate 
• 142355-80-4 methyl 4-piperidin-4-yl>but-2-enoate 
• 142247-38-9 4-[1-(tert-butoxycarbonyl)piperidin-4-yl]butanoic acid 
• 157688-46-5 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid 
• 142374-19-4 tert-butyl 4-(formylmethyl)piperidine-1-carboxylate 
• 89151-44-0 4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester 
• 28356-58-3 pyridine-4-acetic acid 
• 403857-14-7 tert-butyl 4-(but-3-en-1-yl)piperidine-1-carboxylate 
• 165528-85-8 1,1-dimethylethyl 4-(3-oxopropyl)-1-piperidinecarboxylate 
• 156185-63-6 N-Boc-piperidin-4-yl-propanol 

Downstream Products

• 158808-63-0 ethyl 2-(S)-methyl-2-amino>-3-<4-<<piperidin-4-yl>butyl>oxy>phenyl>propionic acid ester 
• 142356-28-3 4-{4-[4-((S)-2-Amino-2-carboxy-ethyl)-phenoxy]-butyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 142373-59-9 4-(4-{4-[(S)-2-(Butane-1-sulfonylamino)-2-carboxy-ethyl]-phenoxy}-butyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 403857-10-3 3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(4-piperidin-4-yl-butoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid 
• 403857-09-0 4-[4-(4-{2-(butane-1-sulfonylamino)-2-[2-(2-carboxy-1,1-dimethyl-ethyl)-3,5-dimethoxy-phenoxycarbonyl]-ethyl}-phenoxy)-butyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 403857-08-9 1-N-Boc-tirofiban-2-[3-[(1-t-butyl-1,1-dimethylsilyl)oxyl]-1,1-dimethylpropyl]-4,6-dimethoxyphenol 
• 150022-77-8 Methyl 3-[4-(4-N-t-Butyloxycarbonylpiperidin-4-yl)butyloxyphenyl]propanoate 
• 158808-64-1 4-{4-[4-((S)-2-Benzyloxycarbonylamino-2-carboxy-propyl)-phenoxy]-butyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 142373-56-6 4-{4-[4-((S)-2-Benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-butyl}-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Buspirone derivative and pharmacy composition comprising the same

The present invention relates to a buspirone derivative and a pharmaceutical composition containing the same and, more specifically, to a novel buspirone derivative and a pharmaceutical composition for treating or preventing hypertension. The buspirone derivative according to the present invention corresponds to a novel derivative of buspirone wherein buspirone have already been known to be effective in the treatment of stress-induced diseases and the novel derivative is effective in the treatment of other diseases. Also, the pharmaceutical composition for treating and preventing blood pressure disorders according to the present invention can treat or prevent blood pressure disorders such as hypertension by using the buspirone derivative to newly widen the use range of buspirone. Particularly, the buspirone derivative enables buspirone, which has been used to treat only stress-induced diseases, to be used for a new purpose of treating hypertension. Also, the present invention has an effect of treating or preventing hypertension as the cause of essential hypertension or primary hypertension is examined closely instead of artificially lowering blood pressure.

Synthesis of cyclic prodrugs of Aggrastat and its analogue with a modified phenylpropionic acid linker

(formula presented) 1a, n=2; 1b, n=1 The objective of this work was to synthesize cyclic prodrugs 1a and 1b from Aggrastat 2a and its analogue 2b, respectively, to improve their membrane permeation. Cyclic prodrugs 1a and 1b were formed using an ester bond between the -COOH group of Aggrastat or its analogue and the phenylpropionic acid linker 3 and an amide bond between the piperidinylamine and the -COOH group of the linker 3, respectively, as outlined in Scheme 4.