142356-62-5

Basic information

• Product Name: 1H-Benzimidazol-2-amine,5,6-difluoro-(9CI)
• Synonyms: 1H-Benzimidazol-2-amine,5,6-difluoro-(9CI);5,6-Difluoro-1H-1,3-benzodiazol-2-amine
• CAS NO: 142356-62-5
• Molecular Formula: C₇H₅F₂N₃
• Molecular Weight: 169.1315064
• Product Categories: BENZIMIDAZOLE
• Mol File: 142356-62-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 378.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.598±0.06 g/cm3(Predicted)
• PKA: 8.03±0.10(Predicted)
• CAS DataBase Reference: 1H-Benzimidazol-2-amine,5,6-difluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazol-2-amine,5,6-difluoro-(9CI)(142356-62-5)
• EPA Substance Registry System: 1H-Benzimidazol-2-amine,5,6-difluoro-(9CI)(142356-62-5)

Safety Data

• Hazardous Substances Data: 142356-62-5(Hazardous Substances Data)

Usage

Organic compound

Yes

Part of the benzimidazole family

Yes

Contains a benzene ring fused to an imidazole ring

Yes

Presence of two fluorine atoms at positions 5 and 6 of the imidazole ring

Yes

Used in the pharmaceutical industry as a building block for the synthesis of biologically active compounds

Yes

Potential as a drug candidate

Yes

Suitable for modification and optimization to develop new and improved pharmaceuticals

Yes

Desired therapeutic properties

Yes

Upstream product

• 506-68-3 bromocyane 
• 76179-40-3 2-amino-4,5-difluoroaniline 
• 78056-39-0 4,5-difluoro-2-nitroaniline 

Downstream Products

• 142356-63-6 2-Chloro-5,6-difulorobenzimidazole 

Relevant articles and documents

New modified 2-aminobenzimidazole nucleosides: Synthesis and evaluation of their activity against herpes simplex virus type 1

Using the enzymatic transglycosylation reaction β-D-ribo- and 2′-deoxyribofuranosides of 2-amino-5,6-difluorobenzimidazole nucleosides have been synthesized. 2-Amino-5,6-difluoro-benzimidazole riboside proved to exhibit a selective antiviral activity (selectivity index >32) against a wild strain of the herpes simplex virus type 1, as well as towards virus strains that are resistant to acyclovir, cidofovir, and foscarnet. We believe that this compound might be used for treatment of herpes infections in those cases, when acyclovir is not efficient.

JAK-2 MODULATORS AND METHODS OF USE

This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention

Preparation and use of aryl alkyl acid derivatives for the treatment of obesity

This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.