142373-60-2 Usage
Description
Tirofiban was launched as Aggrastat in Switzerland and the US for
patients with unstable angina or non-Q-wave myocardial infarction to prevent
cardiac ischemic events. Tirofiban is synthesized from (S)-tyrosine by a fourstep
process. Tirofiban is a novel highly potent antiplatelet agent that inhibits the
interaction of fibrinogen with GPⅡb/Ⅲa, an activated platelet membrane-bound
glycoprotein complex. It prevents arterial thrombus formation in a dosedependent
manner. Clinical efficacy was highly significant with an absolute and
relative risk reduction. In these studies, treatment with tirofiban was well
tolerated, without significant adverse effects.
Originator
Sibutramine (Sibutramine)
Uses
Different sources of media describe the Uses of 142373-60-2 differently. You can refer to the following data:
1. Aggrastat (Millot
Laboratories, France).
2. Tirofiban Hydrochloride is a selective nonpeptide platelet glycoprotein IIb/IIIa antagonist.
Manufacturing Process
The synthesis of tirofiban starts by reaction of tyrosine with bis-trimethylsilyl
trifluoraceramide to give a derivative in which both functions -OH and COOH_x0002_are protected. Treatment of this intermediate with butylsulfonyl chloride gives
the corresponding sulfonamide derivative; the quite labile silyl groups are then
removed under mildly acidic conditions to give N-butylsulfonyl-tyrosine. In a
parallel scheme, 4-picoline is converted to its anion by means of butyl lithium;
this gives 4-(4-chlorobutyl)-pyridine on alkylation with 1-bromo-3-
chloropropane. The reaction of this compound with N-butylsulfonyl-tyrosine in
presence of NaOH gives the ether 2-butylsulfonyaminol-3-[4-pyridin-4-ylbutoxy-phenyl]propionic acid. Hydrogenation over palladium on charcoal then
reduce the pyridine ring to a piperidine to afford the fibrinogen receptor
antagonist tirofiban.
Brand name
Tirofiban is INN and BAN.
Therapeutic Function
Fibrinogen receptor antagonist
Check Digit Verification of cas no
The CAS Registry Mumber 142373-60-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,3,7 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 142373-60:
(8*1)+(7*4)+(6*2)+(5*3)+(4*7)+(3*3)+(2*6)+(1*0)=112
112 % 10 = 2
So 142373-60-2 is a valid CAS Registry Number.
InChI:InChI=1/C23H37NO5S.ClH.H2O/c1-2-3-16-30(27,28)18-21(23(25)26)17-20-7-9-22(10-8-20)29-15-5-4-6-19-11-13-24-14-12-19;;/h7-10,19,21,24H,2-6,11-18H2,1H3,(H,25,26);1H;1H2/t21-;;/m0../s1
