1423740-77-5Relevant academic research and scientific papers
Critical role of a methyl group on the γ-lactone ring of annonaceous acetogenins in the potent inhibition of mitochondrial complex i
Kojima, Naoto,Abe, Masato,Suga, Yuki,Ohtsuki, Kazufumi,Tanaka, Tetsuaki,Iwasaki, Hiroki,Yamashita, Masayuki,Miyoshi, Hideto
, p. 1217 - 1219 (2013/03/28)
C34-epi and C34-epi-C35-trifluoro analogues of solamin, a mono-THF annonaceous acetogenin, were synthesized. Their inhibitory activity, along with previously synthesized analogues (C35-fluoro, C35-difluoro, and C35-trifluorosolamins), against bovine mitochondrial NADH-ubiquinone oxidoreductase (complex I) was determined. The present study revealed that the methyl group on the γ-lactone moiety is critical to the potent inhibition of complex I by natural acetogenins.
