142375-60-8

Basic information

• Product Name: FR 139317
• Synonyms: FR 139317;(HEXAHYDRO-1H-AZEPINYL)CARBONYL-LEU-D-(1-ME)-TRP-DPAL;(HEXAHYDRO-1H-AZEPINYL)CARBONYL-LEU-DTRP(ME)-D-ALA(2-PYRIDYL)-OH;N-[N-[N-[(HEXAHYDRO-1H-AZEPIN-1-YL)CARBONYL]-L-LEUCYL]-1-METHYL-D-TRYPTOPHYL]-3-(2-PYRIDINYL)-D-ALANINE;(N,N-HEXAMETHYLENE) CARBAMOYL-LEU-D-TRP(N-ME)-D-2-PYA;N,N-hexamethylenecarbamoyl-leu-N-*methyl-D-trp-D-;2-((1-(Hexahydro-1H-azepinyl)carbonyl)amino-4-methylpentanoyl)-3-(-(1-methyl-1H-indolyl)propionyl)amino-3-(2-pyridyl)propionic acid;D-Alanine, N-((hexahydro-1H-azepin-1-yl)carbonyl)-L-leucyl-1-methyl-D-tryptophyl-3-(2-pyridinyl)-
• CAS NO: 142375-60-8
• Molecular Formula: C33H44N6O5
• Molecular Weight: 604.74
• Mol File: 142375-60-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 943.9 °C at 760 mmHg
• Flash Point: 524.6 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: Desiccate at +4°C
• CAS DataBase Reference: FR 139317(CAS DataBase Reference)
• NIST Chemistry Reference: FR 139317(142375-60-8)
• EPA Substance Registry System: FR 139317(142375-60-8)

Safety Data

• Hazardous Substances Data: 142375-60-8(Hazardous Substances Data)

Usage

Uses

FR 139317 is a novel, potent endothelin ETA receptor antagonist.

Biological Activity

A highly potent and selective ET A endothelin receptor antagonist (K i values are 1 nM and 7.3 μ M at ET A and ET B subtypes respectively). Active in vivo .

InChI:InChI=1/C33H44N6O5/c1-22(2)18-26(37-33(44)39-16-10-4-5-11-17-39)30(40)35-27(19-23-21-38(3)29-14-7-6-13-25(23)29)31(41)36-28(32(42)43)20-24-12-8-9-15-34-24/h6-9,12-15,21-22,26-28H,4-5,10-11,16-20H2,1-3H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43)/t26-,27+,28+/m0/s1