142387-82-4

Upstream product

• 64-04-0 phenethylamine 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 142387-77-7 (4-{[(E)-2-(2-Bromo-phenyl)-ethylimino]-methyl}-phenyl)-dimethyl-amine 

Relevant academic research and scientific papers

One-step preparation of 1-substituted tetrahydroisoquinolines via the Pictet-Spengler reaction using zeolite catalysts

A new, one-step variation of the Pictet-Spengler reaction has been elaborated using a small pore size zeolite as the catalyst. A new, environmentally friendly variation of the Pictet-Spengler reaction has been elaborated using a small pore size zeolite. The easily separable and recyclable catalyst provided high conversions and a shorter reaction time than the classical acetic acid or trifluoroacetic acid.

Rate constants for aryl radical cyclization of aldimines: Synthesis of tetrahydroisoquinolines by fast 6-endo closures to carbon

Aryl radicals cyclize to an imino functional group in a competition involving 6-endo closure to C and 5-exo closure to N. there is a large 6-endo preference forming tetrahydroisoquinolinyl radicals with k(6-endo) (80°C) > 108 s-1.