1424035-35-7Relevant academic research and scientific papers
Stereospecific Nickel-Catalyzed Borylation of Secondary Benzyl Pivalates
Martin-Montero,Krolikowski,Zarate,Manzano,Martin
, p. 2604 - 2608 (2017)
A stereoselective nickel-catalyzed direct borylation of enantioenriched secondary benzyl pivalates is described. This methodology is characterized by an intriguing cooperativity of simple nickel and copper salts to promote the targeted C-B bond formation under mild reaction conditions. Unlike classical S N 2-type processes, this protocol occurs with a neat retention of configuration, resulting in synthetically versatile benzyl boronic esters with excellent stereochemical fidelity.
Nickel-catalyzed cross-couplings of benzylic pivalates with arylboroxines: Stereospecific formation of diarylalkanes and triarylmethanes
Zhou, Qi,Srinivas, Harathi D.,Dasgupta, Srimoyee,Watson, Mary P.
, p. 3307 - 3310 (2013/04/23)
We have developed a stereospecific nickel-catalyzed cross-coupling of benzylic pivalates with arylboroxines. The success of this reaction relies on the use of Ni(cod)2 as the catalyst and NaOMe as a uniquely effective base. This reaction has broad scope with respect to the arylboroxine and benzylic pivalate, enabling the synthesis of a variety of diarylalkanes and triarylmethanes in good to excellent yields and ee's.
