1424055-75-3Relevant academic research and scientific papers
Iron(II)-catalyzed intramolecular aminohydroxylation of olefins with functionalized hydroxylamines
Liu, Guan-Sai,Zhang, Yong-Qiang,Yuan, Yong-An,Xu, Hao
supporting information, p. 3343 - 3346 (2013/04/23)
A diastereoselective aminohydroxylation of olefins with a functionalized hydroxylamine is catalyzed by new iron(II) complexes. This efficient intramolecular process readily affords synthetically useful amino alcohols with excellent selectivity (dr up to > 20:1). Asymmetric catalysis with chiral iron(II) complexes and preliminary mechanistic studies reveal an iron nitrenoid is a possible intermediate that can undergo either aminohydroxylation or aziridination, and the selectivity can be controlled by careful selection of counteranion/ligand combinations.
