1424137-71-2Relevant academic research and scientific papers
Novel protocol for the synthesis of octahydropyrano- and thiopyrano[4,3-a]carbazole derivatives via Prins/Friedel-Crafts cyclization
Reddy, B. V. Subba,Reddy, P. Sivaramakrishna,Yadav,Sridhar
, p. 1392 - 1396 (2013)
A novel Prins/Friedel-Crafts cyclization of (Z)-6-(1-methyl-1H-indol-3-yl) hex-3-en-1-ol with aldehydes has been achieved using a catalytic amount of BF3·OEt2 under mild reaction conditions to produce the corresponding octahydropyrano[4,3-a]carbazole derivatives in good yields with high diastereoselectivity. The cross-coupling of (Z)-6-(1-methyl-1H-indol- 3-yl)hex-3-ene-1-thiol with aldehydes affords the corresponding octahydrothiopyrano[4,3-a]carbazole derivatives under similar conditions. Copyright
