1424334-96-2

Upstream product

• 2290-65-5 trimethylsilyl isothiocyanate 
• 1424335-12-5 C₂₉H₃₃F₃N₄O₂ 
• 1424335-28-3 C₂₁H₂₃F₃N₄ 
• 1424335-45-4 C₂₁H₂₁F₃N₆ 
• 1417526-58-9 (5-((dimethylamino)methyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-yl)methanol 

Downstream Products

• 1417527-20-8 1-((5-((dimethylamino)methyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one 
• 1417527-21-9 N-(4-fluorobenzyl)-1-(2-((2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)methyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-5-yl)-N,N-dimethylmethanaminium bromide 

Relevant academic research and scientific papers

Design and synthesis of imidazole and triazole derivatives as Lp-PLA 2 inhibitors and the unexpected discovery of highly potent quaternary ammonium salts

New Lp-PLA2 inhibitors were synthesized by the bioisosteric replacement of the amide group of Darapladib with an imidazole or a triazole. Unfortunately, the inhibitory activities of these derivatives were lower than that of Darapladib. But interestingly, a series of quaternary ammonium salts that were isolated as by-products during this synthetic work were found with high potency. Of these by-products, compound 22c showed a similar profile to Darapladib both in vitro and in vivo.