1424338-95-3

Upstream product

• 1424338-86-2 N,N-bis[(1,1-dimethylethoxy)carbonyl]-5-[3′,5′-di-O-(tert-butyldiphenylsilyl)-2′-O-acetyl-β-D-xylofuranosyl]-3-nitro-6-[2-(4-nitrophenyl)ethoxy]-2-pyridinamine 
• 1424338-88-4 N,N-bis[(1,1-dimethylethoxy)carbonyl]-5-(2′-O-acetyl-β-D-xylofuranosyl)-3-nitro-6-[2-(4-nitrophenyl)ethoxy]-2-pyridinamine 
• 1424338-89-5 N,N-bis[(1,1-dimethylethoxy)carbonyl]-5-(5′-O-trityl-2′-O-acetyl-β-D-xylofuranosyl)-3-nitro-6-[2-(4-nitrophenyl)ethoxy]-2-pyridinamine 
• 1424338-92-0 N,N-bis[(1,1-dimethylethoxy)carbonyl]-5-(5′-trityl-3′-deoxy-3′-O-acetyl-β-D-ribofuranosyl)-3-nitro-6-[2-(4-nitrophenyl)ethoxy]-2-pyridinamine 
• 1424338-93-1 5-(3′-deoxy-3′-oxo-2′-O-acetyl-β-D-ribofuranosyl)-3-nitro-6-[2-(4-nitrophenyl)ethoxy]-2-pyridinamine 

Relevant academic research and scientific papers

Ribonucleoside analogs with novel hydrogen bonding patterns

This invention relates to nucleoside, nucleotide, and oligonucleotide analogs that incorporate non-standard nucleobase analogs, defined to be those that present a pattern of hydrogen bonds to a paired nucleobase analog in a complementary strand that is different from the pattern presented by adenine, guanine, cytosine, and thymine. The invention is specifically concerned with nucleotide analogs that present the donor-donor-acceptor, hydrogen bonding patterns on pyrimidine analogs, and especially those that are analogs of ribonucleotides, including protected ribonucleotides suitable for phosphoramidite-based synthesis of RNA. The heterocycles on these nucleoside analogs are aminopyridones that have electron withdrawing groups attached to the position analogous to the 5-position of the ring in standard pyrimidines, including nitro, cyano, and carboxylic acid derivatives.