142457-00-9

Basic information

• Product Name: AMTHAMINE DIHYDROBROMIDE
• Synonyms: 5-ThiazoleethanaMine, 2-aMino-4-Methyl-, dihydrobroMide
• CAS NO: 142457-00-9
• Molecular Formula: C6H13Br2N3S
• Molecular Weight: 319.06052
• Mol File: 142457-00-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 386.3°C at 760 mmHg
• Flash Point: 187.4°C
• Appearance: off-white/
• Vapor Pressure: 1.89E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble27mg/mL
• CAS DataBase Reference: AMTHAMINE DIHYDROBROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: AMTHAMINE DIHYDROBROMIDE(142457-00-9)
• EPA Substance Registry System: AMTHAMINE DIHYDROBROMIDE(142457-00-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 142457-00-9(Hazardous Substances Data)

Usage

General Description

Amthamine dihydrobromide is a chemical compound that is often used in research laboratories as a selective histamine H2 receptor agonist. It acts as a stimulant for the histamine H2 receptor, which is involved in regulating gastric acid secretion. Amthamine dihydrobromide is commonly utilized in studies related to gastrointestinal physiology and the effects of histamine on the stomach. AMTHAMINE DIHYDROBROMIDE has also been used in various pharmaceutical research applications to understand the mechanisms of histamine signaling and to develop potential new drugs for conditions such as gastroesophageal reflux disease and peptic ulcers.

InChI:InChI=1/C6H11N3S.2BrH/c1-4-5(2-3-7)10-6(8)9-4;;/h2-3,7H2,1H3,(H2,8,9);2*1H

Upstream product

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Relevant articles and documents

Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2- aminoethyl)thiazoles

It is well known that both histamine and dimaprit show moderate histamine H2-receptor agonistic activities on the guinea pig right atrium. Quantum chemical calculations on these two compounds showed similarities in electron distributions and molecular electrostatic potentials (MEP's), which could be extended to rigid analogues [2-amino-5-(2-aminoethyl)thiazoles] of the latter structure. On the base of these results a series of substituted 4- and 5-(2- aminoethyl)thiazoles was synthesized applying small alkyl substitution variations as reported for histamine. 2-Amino-5-(2-aminoethyl)-4- methylthiazole (Amthamine) proved to be the most potent full histamine H2- receptor agonist on the guinea pig right atrium, being with a pD2 value of 6.21 slightly more potent than histamine. This compound shows no affinity for H1-receptors and is a full but weak agonist on the histamine H3-receptor with a pD2 value of 4.70, thus showing a marked specificity for histamine H2-receptors. In the 5-(2-aminoethyl)thiazole series the presence of a 2- amino substituent proved to be not essential for stimulation of the histamine H2-receptor, leading to the important conclusion that in contrast to histamine, for this series, acceptance of a proton by the thiazole nucleus of the agonist from the active site of the receptor is sufficient for the stimulation of the histamine H2-receptor.