142458-08-0Relevant articles and documents
Anticonvulsant evaluation and mechanism of action of benzylamino enaminones
Edafiogho, Ivan O.,Ananthalakshmi, Kethireddy V.V.,Kombian, Samuel B.
, p. 5266 - 5272 (2007/10/03)
The mechanism of anticonvulsant action was evaluated for the benzylamino enaminones. The most potent enaminone in this series was the unsubstituted benzylamine analog (30; methyl 4-benzylamino-6-methyl-2-oxocyclohex-3-en-1-oate) which had an oral effective dose (ED50) in rats of 27 mg/kg against maximal electroshock seizures, and a concentration 10-fold less than this dose depressed excitatory synaptic transmission, and action potential firing in the rat brain in vitro.
Synthesis and anticonvulsant activity of enaminones
Edafiogho,Hinko,Chang,Moore,Mulzac,Nicholson,Scott
, p. 2798 - 2805 (2007/10/02)
A new series of novel enaminones has been synthesized from cyclic β- dicarbonyl precursors which were condensed with morpholine, pyrrolidine, phenethylamine, hydrazines, substituted benzyl amines, and substituted anilines. These compounds were subsequentl
