142465-23-4Relevant academic research and scientific papers
Title studies on the reaction of N-(3-carbethoxy-4,5,6,7-tetrahydrobenzo[b] thien-2-yl)-N′-phenylthiourea with hydrazine hydrate (Part 1)
El-Sherief, Hassan A. H.,El-Naggar, Galal M.,Hozien, Zeinab A.,El-Sawaisi, Suliman M.
, p. 467 - 473 (2008/09/19)
(Chemical Equation Presented) The reaction of N-(3-carbethoxy-4,5,6,7- tetrahydrobenzo[b]thien-2-yl)-N′-phenylthiourea (1) with hydrazine hydrate in 1-butanol afforded a mixture of compounds 2, 3 and 4. Treatment of 3 and 4 with nitrous acid gave 6 and 8 respectively, while reactions of 3 with acetylacetone gave 7. Synthesis of tetracyclic compounds 9a-f and 11 from the reactions of 3 with ethyl orthoformate or appropriate acids, acid chloride, carbon disulphide and/or ethyl chloroformate. Also its reaction with isothiocyanate derivatives gave the corresponding thiosemicarbzides 12a,b which on, refluxing in alcoholic KOH gave the unexpected tetracyclic products 14a,b. Similarly the tetracyclic compounds 16a-e and 19 were obtained by cyclization of 4 and 18 respectively.
Synthesis of some triazolothienopyrimidin-5(4H)-ones
Pathak, U S,Gandhi, N V,Singh, S,Warde, R P,Jain, K S
, p. 223 - 229 (2007/10/02)
A series of hitherto unreported 1-(un)substituted-4-phenyltriazolothienopyrimidin-5(4H)-ones (8a-k) have been synthesized by the condensation of 2-hydrazino-3-phenylthienopyrimidin-4(3H)-ones (7a,b) with various one-carbon dono
