1424727-90-1

Basic information

• Product Name: C₁₇H₂₁N₃O₄S
• CAS NO: 1424727-90-1
• Molecular Weight: 363.437
• Mol File: 1424727-90-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₂₁N₃O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₂₁N₃O₄S(1424727-90-1)
• EPA Substance Registry System: C₁₇H₂₁N₃O₄S(1424727-90-1)

Safety Data

• Hazardous Substances Data: 1424727-90-1(Hazardous Substances Data)

Upstream product

• 495406-97-8 methyl 4-hydroxy-8-nitro-quinoline-2-carboxylate 
• 94110-83-5 methyl 4-hydroxy-8-amino-quinoline-2-carboxylate 
• 1424727-82-1 C₁₃H₁₄N₂O₇S₂ 
• 1424727-84-3 C₁₁H₁₀N₂O₅S 
• 108-91-8 cyclohexylamine 

Relevant articles and documents

Amides of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid as zinc-dependent inhibitors of Lp-PLA2

AX10479, the phenyl amide of 4-hydroxy-8-methanesulfonylamino-quinoline-2- carboxylic acid, was identified as a Zn2+-dependent, 27 nM inhibitor of human plasma Lp-PLA2. Structure-activity relationship studies focused on the AX10479 2-phenylamide group identified equipotent cycloaliphatic amides, an enantioselective preference for chiral amides, and phenyl substitution patterns (e.g., 2-methyl-3-fluoro) that increased potency.