142508-71-2

Upstream product

• 19978-32-6 3-bromo-2H-pyran-2-one 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 142508-69-8 (1S,4R,8R)-4-Bromo-8-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxa-bicyclo[2.2.2]oct-5-en-3-one 
• 3966-32-3 (R)-methoxyphenylacetic acid 
• 142508-70-1 (4S,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-hydroxy-cyclohex-1-enecarboxylic acid methyl ester 

Downstream Products

• 142562-61-6 (4R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-4-hydroxy-cyclohex-1-enecarboxylic acid methyl ester 
• 142508-77-8 C₃₄H₅₃O₃PSi₂ 
• 142508-67-6 1α-(hydroxymethyl)-25-(hydroxyvitamin) D₃ 
• 142508-74-5 [(3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methylene-cyclohex-(E)-ylidene]-acetic acid ethyl ester 
• 142562-68-3 [(3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methylene-cyclohex-(E)-ylidene]-acetic acid ethyl ester 
• 142562-64-9 (4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-1-enecarboxylic acid methyl ester 
• 142508-76-7 (1S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-[2-chloro-eth-(E)-ylidene]-2-methylene-cyclohexane 
• 142508-75-6 2-[(3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methylene-cyclohex-(E)-ylidene]-ethanol 
• 142508-73-4 [(4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-1-enyl]-methanol 

Relevant academic research and scientific papers

New vitamin D3 derivatives with unexpected antiproliferative activity: 1-(hydroxymethyl)-25-hydroxyvitamin D3 homologs.

Surprisingly, both of the synthetic 1-(hydroxymethyl)-25-hydroxyvitamin D3 diastereomers (-)-2 and (+)-3 retained the antiproliferative activity of natural calcitriol in murine keratinocytes. Preliminary studies indicated, however, that both of these synt