1425330-62-6

Basic information

• Product Name: ((S)-4-(5-(2-(methylamino)benzamido)pentanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid
• Synonyms: ((S)-4-(5-(2-(methylamino)benzamido)pentanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid
• CAS NO: 1425330-62-6
• Molecular Weight: 435.503
• Mol File: 1425330-62-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ((S)-4-(5-(2-(methylamino)benzamido)pentanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: ((S)-4-(5-(2-(methylamino)benzamido)pentanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid(1425330-62-6)
• EPA Substance Registry System: ((S)-4-(5-(2-(methylamino)benzamido)pentanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid(1425330-62-6)

Safety Data

• Hazardous Substances Data: 1425330-62-6(Hazardous Substances Data)

Upstream product

• 660-88-8 5-aminopentanoic acid 
• 27219-07-4 5-(N-tert-butyloxycarbonyl)aminopentanoic acid 
• 119-68-6 N-Methylanthranilic acid 
• 1425330-46-6 ((S)-4-(5-aminopentanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid 
• 64156-72-5 2-methylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester 
• 1425330-86-4 ((S)-4-(5-((tert-butoxycarbonyl)amino)pentanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid 
• 82518-79-4 N^δ-tert-butoxycarbonylaminovaleric acid N-hydroxysuccinimide ester 

Relevant articles and documents

Design, synthesis, and pharmacological evaluation of fluorescent and biotinylated antagonists of ρ1 GABAC receptors

The ρ1 GABAC receptor is a ligand-gated chloride ion channel that shows promise as a therapeutic target for myopia, sleep disorders, memory and learning facilitation, and anxiety-related disorders. As such, there is a need for molecular probes to understand the role GABA C receptors play in physiological and pathological processes. To date, no labeled (either radioactive or fluorescent) GABAC selective ligand has been developed that can act as a marker for GABAC receptor visualization and localization studies. Herein, we report a series of fluorescent ligands containing different-sized linkers and fluorophores based around (S)-4-ACPBPA [(4-aminocyclopenten-1-yl)-butylphosphinic acid], a selective GABAC antagonist. One of these conjugates, (S)-4-ACPBPA-C5-BODIPY (13), displayed moderate potency (IC50 = 58.61 μM) and selectivity (>100 times) for ρ1 over α1β2γ2L GABAA receptors. These conjugates are novel lead agents for the development of more potent and selective fluorescent probes for studying the localization and function of GABAC receptors in living cells.