142546-45-0Relevant academic research and scientific papers
Protein-resistant surfaces through mild dopamine surface functionalization
Wach, Jean-Yves,Malisova, Barbora,Bonazzi, Simone,Tosatti, Samuele,Textor, Marcus,Zuercher, Stefan,Gademann, Karl
scheme or table, p. 10579 - 10584 (2009/12/04)
The synthesis and evaluation of new dopamine-based catechol anchors coupled to poly(ethylene glycol) (PEG) for surface modification of TiO2 are reported. Dopamine is modified by dimethylamine-methylene (7) or trimethylammonium-methylene (8) groups, and the preparation of mPEG-Glu di-dopamine polymer 11 is presented. All these PEG polymers allow stable adlayers on TiO2 to be generated through mild dip-and-rinse procedures, as evaluated both by variable angle spectroscopic ellipsometry and X-ray photoelectron spectroscopy. The resulting surfaces substantially reduced protein adsorption upon exposure to full human serum.
