142564-20-3

Upstream product

• 18289-89-9 methyl (2R)-2,3-dihydroxypropanoate 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 949087-09-6 (+)-methyl-(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanoate 
• 1096143-66-6 methyl 3-O-tert-butyldiphenylsilyl-(2R)-2-O-(6-O-acetyl-2,3,4-tri-O-benzyl-α-D-glucopyranosyl)-2,3-dihydroxypropanoate 
• 1196978-70-7 C₄₇H₅₂O₉Si 
• 1231671-90-1 methyl (2R)-2-(benzyloxy)-3-(tert-butyldiphenylsilyloxy)propanoate 
• 1231671-93-4 methyl (2R)-2-(tert-butyldimethylsilyloxy)-3-(tert-butyldiphenylsilyloxy)propanoate 
• 1353015-62-9 methyl (2R)-3-(tert-butyldiphenylsilyloxy)-2-[2,3,4,6-tetra-O-acetyl-β-D-mannopyranosyl-(1->2)-6-O-(tert-butyldiphenylsilyl)-3,4-O-(2,3-dimethoxybutane-2,3-diyl)-α-D-glucopyranosyloxy]propanoate 
• 326606-19-3 [4-(tert-butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2-oxo-butyl]-phosphonic acid dimethyl ester 
• 866454-44-6 (2R)-3-[(tert-butyldiphenylsilyl)oxy]-2-(4-methoxybenzyloxy)propanal 
• 949087-14-3 (+)-N,N'-(2-oxopropane-1,3-diyl)bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide] 
• 949087-12-1 (+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide] 

Relevant academic research and scientific papers

A Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining Glycosyltransferase

Glycosyltransferases (GTs) comprise a prominent family of enzymes that play critical roles in a variety of cellular processes, including cell signaling, cell development, and host-pathogen interactions. Glycosyl transfer can proceed with either inversion

Orthogonally protected glycerols and 2-aminodiols: Useful building blocks in heterocyclic chemistry

The efficient synthesis of orthogonally protected glycerols, 2-aminopropane-1,3-diols and 2-aminobutane-1,4-diols that can constitute useful tools in heterocyclic chemistry, is reported. These interesting tri-functionalized small synthons were easily prepared from serine or aspartic acid. In addition, these substrates can be readily transformed into their iodide derivatives in very good yields. ARKAT USA, Inc.

Synthesis of potassium (2R)-2-O-α-d-glucopyranosyl-(1→6)-α-d-glucopyranosyl-2,3-dihydroxypropanoate a natural compatible solute

Ethyl 6-O-acetyl-2,3,4-tribenzyl-1-thio-d-glucopyranoside, as a mixture of anomers, was employed for the stereoselective synthesis of the potassium salt of (2R)-2-O-α-d-glucopyranosyl-(1→6)-α-d-glucopyranosyl-2,3-dihydroxypropanoic acid (α-d-glucosyl-(1→6

Synthetic studies towards 4,10-diaza-1,7-dioxaspiro[5.5]undecanes: access to 3-aza-6,8-dioxabicyclo[3.2.1]octan-2-one and 2H-1,4-oxazin-3(4H)-one frameworks

Synthetic approaches towards 4,10-diaza-1,7-dioxaspiro[5.5]undecanes starting from 1,3-dichloroacetone and solketal derivatives are explored. The method relies on the preparation of a key bis-substituted dihydroxy-protected oxime, which would undergo a final acidic deprotection-spiroacetalization process. Although the desired diazaspiroketal framework could not be obtained, our conditions led to the unexpected 3-aza-6,8-dioxabicyclo[3.2.1]octan-2-one 18 or to the oxazinone 32 in good yields.

Stereochemical assignment of the C1-C6 fragment of psymberin by synthesis and natural product degradation

(Chemical Equation Presented) Psymberin is a sponge-derived natural product that shows striking selectivity as a cytotoxic agent. Conformational mobility has precluded stereochemical assignment for the acyl fragment of this molecule (psymberic acid) by NM

Antiviral and Antitumor Structure-Activity Relationship Studies on Tetracyclic Eudistomines

The in vitro antiviral and antitumor activities of (-)-debromoeudistomin K (1a) and 10 structural analogues (1b-1j and 11) were evaluated.The synthesis was accomplished with an intramolecular Pictet-Spengler condensation reaction as the key step.This exam