1425667-11-3Relevant articles and documents
Diastereoselective Synthesis of 2,6-Disubstituted-1,2,3,6-Tetrahydropyridines through a Palladium-Catalyzed Intramolecular Allylic Amination
Visseq, Alexia,Boibessot, Thibaut,Nauton, Lionel,Théry, Vincent,Anizon, Fabrice,Abrunhosa-Thomas, Isabelle
, p. 7686 - 7702 (2019)
An efficient synthesis of 2,6-disubstituted-1,2,3,6-tetrahydropyridines is reported, featuring a highly diastereoselective palladium-catalyzed intramolecular allylic amination from non-activated alcohols. This method allowed a straightforward access to 2,
Efficient synthesis of β'-amino-α, β-unsaturated ketones
Abrunhosa-Thomas, Isabelle,Plas, Aurelie,Kandepedu, Nishanth,Chalard, Pierre,Troin, Yves
, p. 486 - 495 (2013/04/23)
A general and simple procedure to access chiral β'-amino-α, β-enones, in seven steps, from an α,β unsaturated ester has been described. The use of a Horner-Wadsworth-Emmons reaction as a key step for generating the β'-amino-α,β-enones, permits access to a range of substrates under mild conditions and in moderate to high yield.
Access to 2,6-disubstituted piperidines: Control of the diastereoselectivity, scope, and limitations. applications to the stereoselective synthesis of (-)-solenopsine A and alkaloid (+)-241D
Abrunhosa-Thomas, Isabelle,Plas, Aurelie,Vogrig, Alexandre,Kandepedu, Nishanth,Chalard, Pierre,Troin, Yves
, p. 2511 - 2526 (2013/04/24)
Scope and limitations in the diastereoselective preparation of 2,6-cis or 2,6-trans disubstituted piperidines are described, through intramolecular reaction of chiral β′-carbamate-α,β-unsaturated ketone. This methodology has been applied to the total synthesis of a few well chosen examples, such as (-)-solenopsine A and alkaloid (+)-241D.
