14259-46-2

Basic information

• Product Name: NARIRUTIN
• Synonyms: NARIRUTIN;NARINGENIN-7-RUTINOSIDE;NARINGENIN-7-O-RUTINOSIDE;ISONARINGIN;(S)-7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 7-6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyloxy-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-;NARIRUTIN hplc;NARIRUTIN WITH HPLC
• CAS NO: 14259-46-2
• Molecular Formula: C27H32O14
• Molecular Weight: 580.53
• EINECS: 238-138-0
• Product Categories: Flavanones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 14259-46-2.mol
• Article Data: 0

Chemical Properties

• Melting Point: 162-164°C
• Boiling Point: 924.3 °C at 760 mmHg
• Flash Point: 307.3 °C
• Appearance: off white powder
• Density: 1.66 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.708
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO, Methanol
• PKA: 7.18±0.40(Predicted)
• CAS DataBase Reference: NARIRUTIN(CAS DataBase Reference)
• NIST Chemistry Reference: NARIRUTIN(14259-46-2)
• EPA Substance Registry System: NARIRUTIN(14259-46-2)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 14259-46-2(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Uses

Different sources of media describe the Uses of 14259-46-2 differently. You can refer to the following data:
1. (2S)-Narirutin is a naturally occurring flavonoid that possess anti-allergic, anti-inflammatory, antiproliferative and anti-oxidant properties
2. (2S)-Narirutin is a naturally occurring flavonoid that possess anti-allergic, anti-inflammatory, antiproliferative and anti-oxidant properties.

Definition

ChEBI: A disaccharide derivative that is (S)-naringenin substituted by a 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a lycosidic linkage.

InChI:InChI=1/C27H32O14/c1-10-20(31)22(33)24(35)26(38-10)37-9-18-21(32)23(34)25(36)27(41-18)39-13-6-14(29)19-15(30)8-16(40-17(19)7-13)11-2-4-12(28)5-3-11/h2-7,10,16,18,20-29,31-36H,8-9H2,1H3/t10-,16?,18+,20-,21+,22+,23-,24+,25+,26+,27+/m0/s1

Related news

Application of immunoaffinity purification technology as the pretreatment technology for traditional Chinese medicine: Its application to analysis of hesperidin and NARIRUTIN (cas 14259-46-2) in traditional Chinese medicine preparations containing Citri reticulatae Pericarpium07/23/2019

In the present study, the feasibility of immunoaffinity chromatography (IAC) as a purification technology for the analysis of bioactive components in Traditional Chinese Medicine (TCM) was evaluated. IAC was used to analyze hesperidin (HP) and narirutin (NR) in TCM preparations containing Citri ...detailed

Recovery of NARIRUTIN (cas 14259-46-2) by adsorption on a non-ionic polar resin from a water-extract of Citrus unshiu peels07/22/2019

Narirutin can be successfully recovered from water-extracts of Citrus unshiu peels using the moderately polar acrylic resin, Amberlite XAD-7. The narirutin adsorption yield in this study was determined to be in excess of 95% at the following conditions for XAD-7 resin: three hours of equilibrium...detailed

Optimization of NARIRUTIN (cas 14259-46-2) extraction during washing step of the pectin production from citrus peels07/20/2019

Citrus peels can be a valuable source of pectin and narirutin. Narirutin can be extracted during the washing step of citrus peels in the pectin production process. In this study narirutin extraction conditions were optimized to maximize the narirutin extraction yield while minimized pectin loss....detailed

NARIRUTIN (cas 14259-46-2) fraction from citrus peels attenuates alcoholic liver disease in mice07/21/2019

This study aimed to demonstrate protective activities of the narirutin fraction from peels of Citrus unshiu against ethanol-induced hepatic damage through an animal study. Citrus narirutin fraction (CNF), contained 75% of narirutin, was obtained by an ultra-sonicated extraction and further purif...detailed

Enhanced extraction of flavanones hesperidin and NARIRUTIN (cas 14259-46-2) from Citrus unshiu peel using subcritical water07/19/2019

Flavanones including hesperidin and narirutin constitute the majority of the flavonoids that occur naturally in citrus fruits. The main purpose of this study was to extract valuable natural flavanones from agricultural by-products such as citrus peels using subcritical water extraction (SWE). Th...detailed

NARIRUTIN (cas 14259-46-2) fraction from citrus peels attenuates LPS-stimulated inflammatory response through inhibition of NF-κB and MAPKs activation07/18/2019

In this study, we examined the regulatory activity of narirutin fraction from citrus peels on the production of inflammatory mediators managing acute or chronic inflammatory diseases in macrophages. Narirutin fraction inhibited the release, by lipopolysaccharide (LPS)-stimulated macrophages, of ...detailed

Multi-functional activities of citrus flavonoid NARIRUTIN (cas 14259-46-2) in Alzheimer’s disease therapeutics: An integrated screening approach and in vitro validation07/17/2019

Alzheimer’s disease (AD) is a complex disorder and the disease mechanism is yet to be properly characterized. Over the years, “amyloid cascade” emerges as principal pathogenic event in AD. β-Secretase 1 (BACE1) controls the rate-limiting step in amyloid beta (Aβ) generation and Aβ rapidly ...detailed

Attenuation of isoproterenol-induced cardiotoxicity in rats by NARIRUTIN (cas 14259-46-2) rich fraction from grape fruit07/16/2019

BackgroundOxidative stress is one of the major mechanism involved in pathogenesis of myocardial infarction. Use of natural products as therapeutic approach for ischemic myocardial injury is gaining attention worldwide.detailed