1425946-45-7Relevant academic research and scientific papers
Silver-catalyzed tandem 5- And 6-endo-cyclizationsviaconcomitant yne-ol-imine activation: selective entry to 2-aryldihydrofuroquinolines
Das, Prasanta,Karmakar, Swastik,Kundu, Sandip
supporting information, p. 16112 - 16118 (2021/09/22)
A silver(i) catalyzed domino imination-intramolecular biheterocyclization-aromatization cascade has been developed to construct 2-aryl/-heteroaryl dihydrofuroquinolines in moderate to good yield using an aldehyde and unprotected 4-(2-aminophenyl)but-3-yn-1-ol as precursors. Sequential Ag-(i)-induced 5-endo-digcyclization of the yne-ol part and 6-endo-trigcyclization of a proposed Ag-bound imine, followed by aromatization, furnish the furoquinoline derivatives.
Ru-catalyzed synthesis of dihydrofuroquinolines from azido-cyclopropyl ketones
Yang, Weijun,Xu, Lijun,Chen, Zhengkai,Zhang, Lili,Miao, Maozhong,Ren, Hongjun
, p. 1282 - 1285 (2013/05/09)
An efficient Ru-catalyzed synthesis of dihydrofuroquinolines from azido-cyclopropyl ketones via the reduction-cyclization-rearrangement process is reported. A plausible reaction mechanism for this process is depicted. Additionally, when the reaction was carried out under H2 (1 atm) in the presence of Pd/C, 4-quinolones were obtained in excellent yields.
