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1-(2-fluorobenzyl)piperidine is a chemical compound with the molecular formula C12H16FN. It is a derivative of piperidine, a cyclic amine, with a fluorobenzyl group attached to the nitrogen atom. This fluorinated compound is often used in the synthesis of pharmaceuticals and agrochemicals due to its potential to modulate the properties of the final products, such as increasing lipophilicity or altering metabolic stability. The presence of the fluorine atom can significantly impact the reactivity and binding affinity of the molecule, making it a valuable building block in medicinal chemistry.

1426-74-0

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1426-74-0 Usage

Chemical structure

1-(2-fluorobenzyl)piperidine consists of a piperidine ring with a 2-fluorobenzyl group attached to it.

Class

It is a member of the piperidine class of organic compounds.

Applications

Commonly used in the synthesis of pharmaceuticals and other organic molecules.

2-fluorobenzyl group

A benzene ring with a fluorine atom attached to the 2 position, adding unique properties to the molecule.

Potential applications

Development of new drugs and as an intermediate in organic synthesis.

Safety

Important to handle with care due to potential hazardous properties if not handled properly.

Check Digit Verification of cas no

The CAS Registry Mumber 1426-74-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,2 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1426-74:
(6*1)+(5*4)+(4*2)+(3*6)+(2*7)+(1*4)=70
70 % 10 = 0
So 1426-74-0 is a valid CAS Registry Number.

1426-74-0Downstream Products

1426-74-0Relevant academic research and scientific papers

Palladium(ii)-catalysed ortho-arylation of N-benzylpiperidines

Tan, Peng Wen,Haughey, Maxwell,Dixon, Darren J.

supporting information, p. 4406 - 4409 (2015/03/18)

PdII-catalysed ortho-arylation of benzylic heterocycles with arylboronic acid pinacol esters (Ar-BPin) via directed C-H bond activation to generate the desired biaryl products is reported. This methodology is efficient and applicable to a wide range of functionalised Ar-BPin and benzylic heterocycles, allowing the direct synthesis of important biaryl motifs in modest to good yield. This journal is

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