1426062-85-2Relevant academic research and scientific papers
Synthesis of 4-vinylindoles using ruthenium-catalyzed ring-closing enyne metathesis
Hayashi, Kazushi,Yoshida, Kazuhiro,Yanagisawa, Akira
supporting information, p. 3464 - 3469 (2013/06/26)
The selective synthesis of substituted 4-vinylindoles by the ring-closing enyne metathesis (RCEM)/dehydration sequence is reported. In contrast with many known methods in which a pyrrole ring is constructed onto a functionalized benzene precursor, this method enables the construction of a benzene ring onto a pyrrole precursor. The RCEM/tautomerization sequence for the synthesis of 7-hydroxy-4-vinylindole is also presented as an application of this method.
