1426082-18-9

Basic information

• Product Name: C₂₈H₂₅F₃N₄O₂S
• Synonyms: C₂₈H₂₅F₃N₄O₂S
• CAS NO: 1426082-18-9
• Molecular Weight: 538.593
• Mol File: 1426082-18-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₅F₃N₄O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₅F₃N₄O₂S(1426082-18-9)
• EPA Substance Registry System: C₂₈H₂₅F₃N₄O₂S(1426082-18-9)

Safety Data

• Hazardous Substances Data: 1426082-18-9(Hazardous Substances Data)

Upstream product

• 1426082-42-9 1-(6-bromo-benzo[b]thiophen-3-yl)-2,2,2-trifluoro-ethanol 
• 1426082-41-8 1-(6-bromo-benzo[b]thiophen-3-yl)-2,2,2-trifluoro-ethanone 
• 1426082-37-2 3,6-dibromobenzo[b]thiophene 
• 17347-32-9 6-bromobenzothiophene 
• 105191-64-8 6-Brombenzothiophen-2-carbonsaeure-ethylester 
• 19075-58-2 6-bromo-1-benzothiophene-2-carboxylic acid 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 
• 1251931-22-2 {2-[4-(4-bromo-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-2-yl)-phenoxy]-ethyl}-dimethyl-amine 
• 1251931-23-3 {2-[4-(4-bromo-5-pyridin-4-yl-1H-imidazol-2-yl)-phenoxy]-ethyl}-dimethyl-amine 
• 1426082-61-2 2,2,2-trifluoro-1-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzo[b]thiophen-3-yl]-ethanol 

Relevant articles and documents

Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents

The RAS-RAF-MEK-ERK pathway is hyperactivated in 30% of human cancers. BRAF is a serine-threonine kinase, belonging to this pathway that is mutated with high frequency in human melanoma and other cancers thus BRAF is an important therapeutic target in melanoma. We have designed inhibitors of BRAF based on 2,4,5-trisubstituted imidazoles with naphthyl and benzothiophene-4-substituents. Two compounds were discovered to be potent BRAF inhibitors: 1-(6-{2-[4-(2-dimethylamino-ethoxy)phenyl]-5-(pyridin-4-yl)-1H-imidazol-4-yl} benzo[b]thiophen-3-yl)-2,2,2-trifluoroethanol (1i) with BRAF IC50 = 190 nM and with cellular GI50 = 2100 nM, and 6-{2-[4-(2- dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol (1q) with IC50 = 9 nM and GI50 = 220 nM.