142609-31-2Relevant academic research and scientific papers
Synthesis of pyrrolidin-2-ones by 5-endo-trigonal radical cyclisation of N-vinyl-2,2-bis(phenylsulfanyl)acetamides
sato, Tatsunori,Chono, Noriko,Ishibashi, Hiroyuki,Ikeda, Masazumi
, p. 1115 - 1120 (2007/10/02)
A series of N-methyl-N-(1-substituted or 1,2-disubstituted vinyl)-2,2-bis(phenylsulfanyl)acetamides, upon treatment with tributyltin hydride in the presence of a catalytic amount of AIBN in boiling toluene, underwent smooth cyclisation in a 5-endo-trig ma
A NEW APPROACH TO 5-ARYLPYRROLIDIN-2-ONES VIA 5-ENDO-TRIG RADICAL CYCLIZATION OF α-HALO- OR α-THIO-SUBSTITUTED N-(1-ARYLETHENYL)ACETAMIDES
Sato, Tatsunori,Machigashira, Naomi,Ishibashi, Hiroyuki,Ikeda, Masazumi
, p. 139 - 142 (2007/10/02)
N-(1-Phenylethenyl)carbamoylmethyl radicals generated by tributyltin hydride-mediated cleavage of carbon-halogen or carbon-sulfur bond underwent smooth cyclization in a "disfavored" 5-endo-trig manner to give 5-phenylpyrrolidin-2-one.This method was applied to the synthesis of (+/-)-cotinine.
