142612-75-7

Basic information

• Product Name: 3-Pyrrolidinecarboxylic acid, 1-(4-methoxyphenyl)-2-oxo-4-phenyl-, methyl ester, trans-
• CAS NO: 142612-75-7
• Molecular Formula: C19H19NO4
• Molecular Weight: 325.364
• Mol File: 142612-75-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Pyrrolidinecarboxylic acid, 1-(4-methoxyphenyl)-2-oxo-4-phenyl-, methyl ester, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyrrolidinecarboxylic acid, 1-(4-methoxyphenyl)-2-oxo-4-phenyl-, methyl ester, trans-(142612-75-7)
• EPA Substance Registry System: 3-Pyrrolidinecarboxylic acid, 1-(4-methoxyphenyl)-2-oxo-4-phenyl-, methyl ester, trans-(142612-75-7)

Safety Data

• Hazardous Substances Data: 142612-75-7(Hazardous Substances Data)

Upstream product

• 142613-21-6 N-(4-Methoxy-phenyl)-N-phenethyl-malonamic acid methyl ester 
• 103-63-9 1-phenyl-2-bromoethane 
• 2405-59-6 N-(2-phenylethyl)-4-methoxyaniline 
• 14803-72-6 methyl N-(4-methoxyphenyl)carbamate 
• 142612-59-7 N-phenylethyl-N-p-methoxyphenyl-α-methoxycarbonyl-α-diazoacetamide 

Relevant articles and documents

Enantioselective synthesis of 4-substituted 2-pyrrolidinones by site- selective C-H insertion of α-methoxycarbonyl-α-diazoacetanilides catalyzed by dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate]

Site- and enantioselective intramolecular C-H insertion of α- methoxycarbonyl-α-diazoacetamides has been achieved by exploiting a p- nitrophenyl group as the N-substituent and dirhodium(II) tetrakis[N- phthaloyl-(S)-tert-leucinate] as catalyst, leading to the formation of 4 substituted 2-pyrrolidinone derivatives of up to 82% ee. The efficiency of the present protocol has been verified well by a short-step synthesis of (R)- (-)-baclofen.