1426146-57-7

Basic information

• Product Name: (R)-(4-tert-butylphenyl)(4-chlorophenyl)methyl acetate
• Synonyms: (R)-(4-tert-butylphenyl)(4-chlorophenyl)methyl acetate
• CAS NO: 1426146-57-7
• Molecular Weight: 316.828
• Mol File: 1426146-57-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-(4-tert-butylphenyl)(4-chlorophenyl)methyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(4-tert-butylphenyl)(4-chlorophenyl)methyl acetate(1426146-57-7)
• EPA Substance Registry System: (R)-(4-tert-butylphenyl)(4-chlorophenyl)methyl acetate(1426146-57-7)

Safety Data

• Hazardous Substances Data: 1426146-57-7(Hazardous Substances Data)

Upstream product

• 108-22-5 Isopropenyl acetate 
• 130210-29-6 C₁₇H₁₉ClO 

Relevant articles and documents

Dynamic kinetic resolution of diarylmethanols with an activated lipoprotein lipase

We explored the kinetic resolution of 31 different diarylmethanols with an activated lipoprotein lipase (LPL-D1) which was about 3000-fold more active than its native counterpart in organic solvent. Most of the substrates tested were accepted by LPL-D1 with good to high enantioselectivity in the kinetic resolution. Next, we explored the dynamic kinetic resolutions (DKRs) of these substrates (24 out of 31) using LPL-D1 and a ruthenium-based racemization catalyst in combination, which provided satisfactory yields (71-96%) and high enantiopurities (90-99% ee). As an illustrative example for the synthetic applications of the DKR procedure, we synthesized L-cloperastine, an antitussive drug, from phenyl-(p-trimethylsilylphenyl)methanol via DKR. (Chemical Equation Presented).