1426239-86-2Relevant academic research and scientific papers
Nucleoterpenes of thymidine and 2′-deoxyinosine: Synthons for a biomimetic lipophilization of oligonucleotides
K?stler, Karl,Werz, Emma,Malecki, Edith,Montilla-Martinez, Malayko,Rosemeyer, Helmut
, p. 39 - 61 (2013)
2′-Deoxyinosine (1) and thymidine (7) were N-alkylated with geranyl and farnesyl moieties. These hydrophobic derivatives, 3a and 3b, and 9a and 9b, respectively, represent the first synthetic biomimetic nucleoterpenes and were subsequently 5′-protected an
REACTIVE, LIPOPHILIC NUCLEOSIDE BUILDING BLOCKS FOR THE SYNTHESIS OF HYDROPHOBIC NUCLEIC ACIDS
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Paragraph 0387; 0388, (2019/06/20)
The present invention relates to a method for the isolation and/or identification of known or unknown sequences of nucleic acids (target sequences) optionally marked with reporter groups by base specific hybridation with complementary sequences using nucleolipids. The nucleolipids are prepared by lipophilizing nucleosides of formula (Ia) wherein Q represents a group having a substituted tetrahydrofuran ring and Bas represents a group having one or more heterocyclic rings having one or more heterocyclic nitrogen atoms.
Reactive, lipophilic nucleoside building blocks for the synthesis of hydrophobic nucleic acids
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Paragraph 0111; 0112, (2014/05/06)
The present invention relates to a method for the isolation and/or identification of known or unknown sequences of nucleic acids (target sequences) optionally marked with reporter groups by base specific hybridation with, essentially, complementary sequences (in the following referred to as sample oligonucleotides, sample sequences or sample nucleic acids), which belong to a library of sequences. Further, the invention relates to nucleolipids used in the method of the invention and a process for the preparation of said nucleolipids.
