1426258-44-7

Basic information

• Product Name: 4-chloro-1-[(3,4-dichlorophenyl)carbamoyl]phenyl pyrazine-2-carboxylate
• CAS NO: 1426258-44-7
• Molecular Weight: 422.655
• Mol File: 1426258-44-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-1-[(3,4-dichlorophenyl)carbamoyl]phenyl pyrazine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-1-[(3,4-dichlorophenyl)carbamoyl]phenyl pyrazine-2-carboxylate(1426258-44-7)
• EPA Substance Registry System: 4-chloro-1-[(3,4-dichlorophenyl)carbamoyl]phenyl pyrazine-2-carboxylate(1426258-44-7)

Safety Data

• Hazardous Substances Data: 1426258-44-7(Hazardous Substances Data)

Upstream product

• 98-97-5 2-pyrazylcarboxylic acid 
• 58622-66-5 4-chloro-N-(3,4-dichlorophenyl)-2-hydroxybenzamide 

Relevant articles and documents

In vitro antibacterial and antifungal activity of salicylanilide pyrazine-2-carboxylates

The development of new antimicrobial agents for the treatment of infectious diseases remains challenging due to the increasing impact of antibiotic resistance. Since salicylanilides and esters of pyrazine-2-carboxylic acid have been described as potential antimicrobials, we have designed and synthesized a series of 2-(phenylcarbamoyl)phenyl pyrazine-2-carboxylates. These were evaluated in vitro for the activity against fungi and Gram-positive and Gram-negative bacteria. All derivatives showed significant antibacterial activity against Gram-positive strains (MIC ≥ 0.98 μmol/L) including methicillin-resistant Staphylococcus aureus. The most active molecule was 5-chloro-2-(3-chlorophenylcarbamoyl)phenyl pyrazine-2-carboxylate. With one exception these esters were at least partly active against fungi tested strains, in particular against mould strains (MIC ≥ 1.95 μmol/L). The most active antifungal agent overall proved to be 2-(4-bromophenylcarbamoyl)-4-chlorophenyl pyrazine-2-carboxylate.