1426259-35-9 Usage
Uses
Used in Pharmaceutical Industry:
(6-methylpyridin-2-yl)-[4-(4-pyridin-3-yl-phenyl)thiazol-2-yl]amine is used as a potential pharmaceutical compound for its possible biological activity. The presence of pyridine and thiazole rings, along with the amine group, indicates that this chemical may have applications in the development of new drugs, particularly those targeting various diseases or conditions.
Used in Chemical Research:
In the field of chemical research, (6-methylpyridin-2-yl)-[4-(4-pyridin-3-yl-phenyl)thiazol-2-yl]amine can be used as a subject for studying the effects of its molecular structure on its properties and reactivity. This may lead to a better understanding of how to design and synthesize new compounds with specific characteristics and potential applications.
Used in Material Science:
(6-methylpyridin-2-yl)-[4-(4-pyridin-3-yl-phenyl)thiazol-2-yl]amine may also find use in material science, particularly in the development of new materials with unique properties. The combination of pyridine and thiazole rings, along with the amine group, could potentially contribute to the creation of materials with specific electronic, optical, or mechanical properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1426259-35-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,6,2,5 and 9 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1426259-35:
(9*1)+(8*4)+(7*2)+(6*6)+(5*2)+(4*5)+(3*9)+(2*3)+(1*5)=159
159 % 10 = 9
So 1426259-35-9 is a valid CAS Registry Number.
1426259-35-9Relevant academic research and scientific papers
2-Aminothiazoles with Improved Pharmacotherapeutic Properties for Treatment of Prion Disease
Li, Zhe,Silber, B. Michael,Rao, Satish,Gever, Joel R.,Bryant, Clifford,Gallardo-Godoy, Alejandra,Dolghih, Elena,Widjaja, Kartika,Elepano, Manuel,Jacobson, Matthew P.,Prusiner, Stanley B.,Renslo, Adam R.
, p. 847 - 857 (2013/08/25)
Recently, we described the aminothiazole lead (4-biphenyl-4-ylthiazol-2-yl)-(6-methylpyridin-2-yl)-amine (1), which exhibits many desirable properties, including excellent stability in liver microsomes, oral bioavailability of ～40%, and high exposure in the brains of mice. Despite its good pharmacokinetic properties, compound 1 exhibited only modest potency in mouse neuroblastoma cells overexpressing the disease-causing prion protein PrPSc. Accordingly, we sought to identify analogues of 1 with improved antiprion potency in ScN2a-cl3 cells while retaining similar or superior properties. Herein we report the discovery of improved lead compounds such as (6-methylpyridin-2-yl)-[4-(4-pyridin-3-yl-phenyl)thiazol-2-yl]amine and cyclopropanecarboxylic acid (4-biphenylthiazol-2-yl)amide, which exhibit brain exposure/EC50 ratios at least tenfold greater than that of compound 1.
