142628-88-4

Basic information

• Product Name: 4-(2-PHENYLETHYL)-PIPERIDINE HYDROCHLORIDE
• Synonyms: 4-(2-PHENYLETHYL)-PIPERIDINE HYDROCHLORIDE;REF DUPL: 4-phenethylpiperidine hydrochloride;Piperidine, 4-(2-phenylethyl)-, hydrochloride;4-Phenethyl-piperidine HCl;Piperidine, 4-(2-phenylethyl)-, hydrochloride (1:1)
• CAS NO: 142628-88-4
• Molecular Formula: C₁₃H₁₉N*ClH
• Molecular Weight: 225.76
• Mol File: 142628-88-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 147-152 °C
• Appearance: /
• CAS DataBase Reference: 4-(2-PHENYLETHYL)-PIPERIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-PHENYLETHYL)-PIPERIDINE HYDROCHLORIDE(142628-88-4)
• EPA Substance Registry System: 4-(2-PHENYLETHYL)-PIPERIDINE HYDROCHLORIDE(142628-88-4)

Safety Data

• Hazardous Substances Data: 142628-88-4(Hazardous Substances Data)

Usage

General Description

4-(2-Phenylethyl)-piperidine hydrochloride is a chemical compound with the molecular formula C13H20ClN. It is a piperidine derivative, and its hydrochloride salt form is commonly used as a pharmaceutical intermediate. The compound has potential psychoactive effects, as it acts as a dopamine receptor agonist, and it is being researched for its potential use in the treatment of central nervous system disorders. Its structure includes a piperidine ring substituted with a phenethyl group, and the hydrochloride salt form makes it more water-soluble and suitable for pharmaceutical applications. It has also been studied for its potential use as a local anesthetic.

Upstream product

• 125769-59-7 4-benzo[b]selenophen-2-yl-pyridine 
• 5097-93-8 trans-4-styrylpyride 

Downstream Products

• 159305-12-1 1-acetyl-3-(4-phenethylpiperidin-1-ylmethyl)-1H-indazole 
• 142498-75-7 1-(3,4-dihydro-2-oxo-1H-quinolin-6-yl)-2-[4-(2-phenylethyl)piperidin-1-yl]ethanol 
• 221282-07-1 2-Phenyl-3-[2-(4-(2-phenylethyl)piperidin-1-yl)ethyl]-1H-indole 

Relevant articles and documents

Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B

The resurgence of interest in monoamine oxidases (MAOs) has been fueled by recent correlations of this enzymatic activity with cardiovascular, neurological, and oncological disorders. This has promoted increased research into selective MAO-A and MAO-B inhibitors. Here, we shed light on how selective inhibition of MAO-A and MAO-B can be achieved by geometric isomers of cis-and trans-1-propargyl-4-styrylpiperidines. While the cis isomers are potent human MAO-A inhibitors, the trans analogues selectively target only the MAO-B isoform. The inhibition was studied by kinetic analysis, UV-vis spectrum measurements, and X-ray crystallography. The selective inhibition of the MAO-A and MAO-B isoforms was confirmed ex vivo in mouse brain homogenates, and additional in vivo studies in mice show the therapeutic potential of 1-propargyl-4-styrylpiperidines for central nervous system disorders. This study represents a unique case of stereoselective activity of cis/trans isomers that can discriminate between structurally related enzyme isoforms.