142629-81-0

Basic information

• Product Name: 3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate
• Synonyms: 3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate
• CAS NO: 142629-81-0
• Molecular Formula: C₂₀H₂₅N₆O₈P
• Molecular Weight: 508.421661
• Mol File: 142629-81-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate(142629-81-0)
• EPA Substance Registry System: 3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate(142629-81-0)

Safety Data

• Hazardous Substances Data: 142629-81-0(Hazardous Substances Data)

Upstream product

• 30516-87-1 3'-azido-2',3'-deoxythymidine 
• 142629-80-9 phenyl methoxyalaninyl phosphorochloridate 
• 108-95-2 phenol 
• 3426-89-9 phenyl phosphorodichloridite 
• 770-12-7 O-phenyl phosphorodichloridate 
• 10065-72-2 L-Alanine methyl ester 
• 834918-59-1 C₁₆H₁₈N₅O₆P 

Downstream Products

• 244127-85-3 2(S)-(3-deoxy-3-azidothymidyl(hydroxy)phosphorylamino)propionic acid methyl ester 
• 108-95-2 phenol 

Relevant articles and documents

Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model

The anti-proliferative effects of a novel bromomethoxylated arylphosphate derivative of zidovudine (compound DDE46, CAS 213982-96-8) were first examined in a zebra fish embryo model. DDE46 blocked the cell division at the 2-cell stage of the embryonic development followed by total cell fusion. DDE46 also inhibited the proliferation of the leukemic cell lines NALM-6 and MOLT-3. DDE46 enhanced the activity of the pro-apoptotic enzymes Caspase-3, Caspase-6, Caspase-8, and Caspase-9 leading to the apoptotic death of the leukemic cell line Jurkat. These results justify the further development of this agent as a new anti-leukemic drug candidate. ECV · Editio Cantor Verlag, Aulendorf (Germany).