1426318-97-9Relevant academic research and scientific papers
Enantioselective oxidative functionalization of the Csp3-H bond adjacent to a nitrogen atom for rapid access to β-hydroxyl-α-amino acid derivatives
Qiu, Lin,Guo, Xin,Qian, Yu,Jing, Changcheng,Ma, Chaoqun,Liu, Shunying,Hu, Wenhao
supporting information, p. 11831 - 11833 (2016/10/09)
Highly chemoselective and enantioselective one-pot reactions involved in the oxidative functionalization of Csp3-H bonds adjacent to nitrogen atoms in N-aryl glycine esters were developed. The method provided rapid access to a variety of highly functionalized β-hydroxyl-α-amino acid derivatives from simple starting materials under mild conditions.
Optically active α-amino group of the β-hydroxy amino acid derivative and its preparation method and application
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Paragraph 0079-0081, (2016/10/24)
The invention relates to an alpha-amino beta-hydroxy amino acid derivative shown as formula (I) with optical activity and a preparation method and application thereof, the alpha-amino beta-hydroxy amino acid derivative with optical activity is obtained by the reaction of three components at-10 DEG C by sue of a diazo compound, N-aryl substituted glycine ester, 2, 3-dichloro-5, 6-dicyano-1, 4 - benzoquinone and water as raw materials, rhodium acetate and chiral phosphoric acid as catalysts and an organic solvent as a solvent. The raw materials are cheap and easily obtained, two chiral carbons can be simultaneously constructed, the preparation route is short, the operation is simple and safe, the reaction condition is mild, the atom economy is high, the selectivity is high, and the alpha-amino beta-hydroxy amino acid derivative can be conveniently obtained, and diverse compound skeletons can be provided for use in screening of new drugs and pharmaceutical fields.
