1426327-86-7Relevant academic research and scientific papers
Synthesis of functionalized spiroindolines via palladium-catalyzed methine C-H arylation
Saget, Tanguy,Perez, David,Cramer, Nicolai
, p. 1354 - 1357 (2013/05/09)
The synthesis of cyclopropyl spiroindolines is described using an intramolecular palladium(0)-catalyzed C-H functionalization of a methine C(sp3)-H bond. This transformation can be coupled with intermolecular Suzuki couplings or direct arylations of heteroaromatics to access functionalized indoline scaffolds in a single step.
Palladium(0)-catalyzed enantioselective C-H arylation of cyclopropanes: Efficient access to functionalized tetrahydroquinolines
Saget, Tanguy,Cramer, Nicolai
, p. 12842 - 12845 (2013/02/22)
Activated: The title reaction proceeds efficiently with 1 mol % of palladium and gives tetrahydroquinolines in excellent enantioselectivities (see scheme). The enantiodiscriminating concerted metalation-deprotonation step occurs via a rare seven-membered palladacycle. The cyclopropyl-substituted tetrahydroquinolines can be regioselectively and enantiospecifically reduced to chiral tetrahydrobenzoazepines. Copyright
