1426329-35-2

Upstream product

• 24398-88-7 ethyl 3-bromobenzoate 
• 1426329-34-1 4-(3-bromophenyl)-8-nitro-1H-benzo [b][1,4]diazepin-2(3H)-one 
• 21575-91-7 ethyl 3-bromobenzoylacetate 
• 99-56-9 4-Nitrophenylene-1,2-diamine 

Downstream Products

• 1426328-82-6 benzyl (4-(3-bromophenyl)-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-8-yl)carbamate 
• 1426328-60-0 N-(4-(3-cyanophenyl)-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-8-yl)acetamide 
• 1426328-62-2 N-(4-(3-cyanophenyl)-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-8-yl)methanesulfonamide 
• 1426328-84-8 phenyl (4-(3-cyanophenyl)-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-8-yl)carbamate 
• 1426328-85-9 benzyl(4-(3-cyanophenyl)-2-oxo-2,3-dihydro-1H-benzo [b][1,4]diazepin-8-yl)carbamate 
• 1426328-92-8 1-benzyl-3-(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-8-yl)urea 
• 1426328-93-9 1-benzyl-3-(4-(3-cyanophenyl)-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-8-yl)urea 
• 1426328-94-0 1-(4-(3-cyanophenyl)-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-8-yl)-3-phenylurea 
• 1426329-37-4 1-benzyl-3-(2-oxo-4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2,3-dihydro-1H-benzo[b][1,4]diazepin-8-yl)urea 
• 1426328-83-7 phenyl(4-(3-bromophenyl)-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-8-yl)carbamate 
• 1426328-59-7 3-(8-amino-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)benzonitrile 
• 1426328-90-6 1-benzyl-3-(4-(3-bromophenyl)-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-8-yl)urea 

Relevant academic research and scientific papers

METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

NOVEL BENZODIAZEPINONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR FUNCTIONS AND NEUROLOGICAL USES THEREOF

The present invention relates to novel benzodiazepinone compounds of Formulae (I) wherein R1, R2, R4, R6, R7, R8, R9, and R10 are as defined herein. The invention also