142633-89-4

Upstream product

• 667457-65-0 ((E)-(1R,3R)-3-Hydroxy-1-vinyl-hex-4-enyl)-carbamic acid tert-butyl ester 
• 60410-16-4 (1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate 
• 667457-58-1 (R)-(-)-N-(tert-butoxycarbonyl)-6-amino-4-oxo-nona-2,7-diene 
• 667457-57-0 (R)-(-)-N-(tert-butoxycarbonyl)-6-amino-4-oxo-octa-2,7-diene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 657397-01-8 (2R)-(4-oxocyclopent-2-enyl)-carbamic acid tert-butyl ester 
• 142633-88-3 (1R,4R)-trans-1-acetoxy-4-<<(tert-butyloxy)carbonyl>amino>-2-cyclopentene 
• 142633-87-2 (1R,4R)-trans-1-acetoxy-4-(N-phthalimidoamino)-2-cyclopentene 
• 75694-91-6 (1R,4R)-trans-1-acetoxy-4-amino-2-cyclopentene 
• 667457-52-5 (S_S,R)-(+)-dimethyl [2-oxo-4-(p-toluenesulfinylamino)-hept-5-enyl]-phosphonate 
• 667457-51-4 (S_S,R)-(+)-dimethyl [2-oxo-4-(p-toluenesulfinylamino)-hex-5-enyl]-phosphonate 
• 667457-54-7 (S_S,R)-(+)-N-(p-toluenesulfinyl)-6-amino-4-oxo-nona-2,7-diene 
• 667457-62-7 (S_S,4R,6R)-(+)-N-(p-toluenesulfinyl)-6-aminoocta-2,7-dien-4-ol 
• 667457-53-6 (S_S,R)-(+)-N-(p-toluenesulfinyl)-6-amino-4-oxo-octa-2,7-diene 

Relevant academic research and scientific papers

Addition of Lithium Anion of (Acetylmethylene)triphenylphosphorane to Nonracemic Sulfinimines: Total Synthesis of (+)-241D and Formal Total Synthesis of (+)-Preussin

The addition of lithium anion of (acetylmethylene)triphenylphosphorane to nonracemic sulfinimines was investigated. It was found that the addition proceeded with good diastereoselectivity and further reaction of the formed sulfinimidophosphorane with seve

Asymmetric synthesis of the carbocyclic nucleoside building block (R)-(+)-4-aminocyclopentenone using δ-amino β-ketophosphonates and ring-closing metathesis (RCM)

Amino keto-2,7-dienes undergo ring-closing metathesis (RCM) to give 4-aminocyclopentenones, valuable intermediates in the asymmetric construction of carbocyclic nucleosides. The key amino ketodienes were prepared using δ-amino β-ketophophonates, a new sul

S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-(methylsulfonio)-2-cyclopentene: A potent, enzyme-activated irreversible inhibitor of S-adenosylmethionine decarboxylase

The compound S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-(methylsulfonio)-2- cyclopentene (AdoMac) was prepared and evaluated as an irreversible inhibitor of S-adenosylmethionine decarboxylase (AdoMet-DC). AdoMac was shown to inhibit AdoMet-DC in a time-dependent manner with a K(I) of 18.3 μM and a k(inact) of 0.133 min-1. In addition, AdoMet-DC activity could not be restored following extensive dialysis of the enzyme-inhibitor complex, and the enzyme was protected from irreversible inactivation by the known competitive inhibitor methylglyoxal bis(guanylhydrazone). HPLC analysis of the enzymatic reaction products revealed a time-dependent decrease in the peak coeluting with AdoMac, and a corresponding increase in the peak coeluting with (methylthio)adenosine (MTA), a byproduct of the irreversible binding of AdoMac to the enzyme. Thus, AdoMac appears to function as an enzyme-activated, irreversible inhibitor of AdoMet-DC.