142633-89-4

Basic information

• Product Name: Carbamic acid, [(1R,4R)-4-hydroxy-2-cyclopenten-1-yl]-, 1,1-dimethylethyl
• Synonyms: Carbamic acid, [(1R,4R)-4-hydroxy-2-cyclopenten-1-yl]-, 1,1-dimethylethyl
• CAS NO: 142633-89-4
• Molecular Formula: C10H17NO3
• Molecular Weight: 199.24688
• Product Categories: N-BOC
• Mol File: 142633-89-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [(1R,4R)-4-hydroxy-2-cyclopenten-1-yl]-, 1,1-dimethylethyl(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R,4R)-4-hydroxy-2-cyclopenten-1-yl]-, 1,1-dimethylethyl(142633-89-4)
• EPA Substance Registry System: Carbamic acid, [(1R,4R)-4-hydroxy-2-cyclopenten-1-yl]-, 1,1-dimethylethyl(142633-89-4)

Safety Data

• Hazardous Substances Data: 142633-89-4(Hazardous Substances Data)

Upstream product

• 142633-87-2 (1R,4R)-trans-1-acetoxy-4-(N-phthalimidoamino)-2-cyclopentene 
• 75694-91-6 (1R,4R)-trans-1-acetoxy-4-amino-2-cyclopentene 
• 60410-16-4 (1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate 
• 667457-52-5 (S_S,R)-(+)-dimethyl [2-oxo-4-(p-toluenesulfinylamino)-hept-5-enyl]-phosphonate 
• 667457-51-4 (S_S,R)-(+)-dimethyl [2-oxo-4-(p-toluenesulfinylamino)-hex-5-enyl]-phosphonate 
• 667457-54-7 (S_S,R)-(+)-N-(p-toluenesulfinyl)-6-amino-4-oxo-nona-2,7-diene 
• 667457-62-7 (S_S,4R,6R)-(+)-N-(p-toluenesulfinyl)-6-aminoocta-2,7-dien-4-ol 
• 667457-53-6 (S_S,R)-(+)-N-(p-toluenesulfinyl)-6-amino-4-oxo-octa-2,7-diene 
• 667457-58-1 (R)-(-)-N-(tert-butoxycarbonyl)-6-amino-4-oxo-nona-2,7-diene 
• 667457-57-0 (R)-(-)-N-(tert-butoxycarbonyl)-6-amino-4-oxo-octa-2,7-diene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 667457-65-0 ((E)-(1R,3R)-3-Hydroxy-1-vinyl-hex-4-enyl)-carbamic acid tert-butyl ester 
• 657397-01-8 (2R)-(4-oxocyclopent-2-enyl)-carbamic acid tert-butyl ester 
• 142633-88-3 (1R,4R)-trans-1-acetoxy-4-<<(tert-butyloxy)carbonyl>amino>-2-cyclopentene 

Relevant articles and documents

Addition of Lithium Anion of (Acetylmethylene)triphenylphosphorane to Nonracemic Sulfinimines: Total Synthesis of (+)-241D and Formal Total Synthesis of (+)-Preussin

The addition of lithium anion of (acetylmethylene)triphenylphosphorane to nonracemic sulfinimines was investigated. It was found that the addition proceeded with good diastereoselectivity and further reaction of the formed sulfinimidophosphorane with seve

S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-(methylsulfonio)-2-cyclopentene: A potent, enzyme-activated irreversible inhibitor of S-adenosylmethionine decarboxylase

The compound S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-(methylsulfonio)-2- cyclopentene (AdoMac) was prepared and evaluated as an irreversible inhibitor of S-adenosylmethionine decarboxylase (AdoMet-DC). AdoMac was shown to inhibit AdoMet-DC in a time-dependent manner with a K(I) of 18.3 μM and a k(inact) of 0.133 min-1. In addition, AdoMet-DC activity could not be restored following extensive dialysis of the enzyme-inhibitor complex, and the enzyme was protected from irreversible inactivation by the known competitive inhibitor methylglyoxal bis(guanylhydrazone). HPLC analysis of the enzymatic reaction products revealed a time-dependent decrease in the peak coeluting with AdoMac, and a corresponding increase in the peak coeluting with (methylthio)adenosine (MTA), a byproduct of the irreversible binding of AdoMac to the enzyme. Thus, AdoMac appears to function as an enzyme-activated, irreversible inhibitor of AdoMet-DC.