1426428-00-3Relevant articles and documents
Synthesis of trisaccharides incorporating the a-Gal antigen functionalized for neoglycoconjugate preparation
Plaza-Alexander, Patrice,Lowary, Todd L.
, p. 112 - 122,11 (2020/09/02)
The synthesis of trisaccharides 1 and 2, which contain the a-D-galactopyranosyl-(1→3)-β-Dgalactopyranosyl (a-Gal) motif, is described. A key step in the synthesis of the trisaccharides was the glycosylation of a monosaccharide acceptor with a disaccharide trichloroacetimidate donor. Subsequent modification of the products of this [2+1] glycosylation afforded 1 and 2, which contain an activated ester moiety suitable for reaction with, for example, proteins or amine-coated surfaces.