1426430-09-2Relevant articles and documents
Synthesis of biotinylated episilvestrol: Highly selective targeting of the translation factors eIF4AI/II
Chambers, Jennifer M.,Lindqvist, Lisa M.,Webb, Andrew,Huang, David C. S.,Savage, G. Paul,Rizzacasa, Mark A.
, p. 1406 - 1409 (2013/05/08)
Silvestrol (1) and episilvestrol (2) are protein synthesis inhibitors, and the former has shown efficacy in multiple mouse models of cancer; however, the selectivity of these potent cytotoxic natural products has not been described. Herein, it is demonstr