1426431-48-2Relevant academic research and scientific papers
Trifluoroethanol and liquid-assisted grinding method: a green catalytic access for multicomponent synthesis
Lohar, Trushant,Mane, Ananda,Kamat, Siddharth,Kumbhar, Arjun,Salunkhe, Rajashri
, p. 1919 - 1933 (2017/12/06)
An efficient and versatile mechanochemical route for the synthesis of chromene and isoindolo[2,1-a]quinazoline scaffolds has been developed via a simple mortar and pestle liquid-assisted grinding method using 2,2,2-trifluoroethanol (TFE) as an efficient catalyst. The present protocol is very efficient as it offers reaction in mild reaction condition, cleaner reaction profiles, effortless work-up step with excellent purity, and high yield of the desired products with short reaction time.
Studies on novel synthetic methodologies, part XII: An efficient one-pot access to 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-diones and 5-phenylisoindolo[2,1-a]quinazolin-11(6a H)-ones
Sashidhara, Koneni V.,Palnati, Gopala Reddy,Dodda, Ranga Prasad,Avula, Srinivasa Rao,Swami, Priyanka
supporting information, p. 105 - 113 (2013/02/23)
A simple and efficient procedure for the construction of 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione and 5-phenylisoindolo[2,1-a] quinazolin-11(6aH)-one derivatives in acetic acid under catalyst-free conditions is described. Attractive features of this methodology are its versatility, ready availability of starting materials and the efficiency in creating a complex core in a single operation. Georg Thieme Verlag Stuttgart · New York.
