142645-79-2

Upstream product

• 4855-96-3 3,17-bis(ethylenedioxy)-androst-5-en-19-al 
• 98-59-9 p-toluenesulfonyl chloride 
• 143060-79-1 3-<3,3:17,17-bis<1,2-ethanediylbis(oxy)>estr-5-en-10-yl>-2-propenoic aci ethyl ester 
• 142645-77-0 10-(3-hydroxypropyl)estr-5-ene-3,17-dione cyclic bis(1,2-ethanediyl acetal) 
• 142645-78-1 3,3,17,17-bis(ethylenedioxy)-19-[2-(4-toluenesulfonyloxy)ethyl]androst-5-ene 

Downstream Products

• 142645-70-3 (4α,10α)-4,19-cyclo-A-dihomoandrost-4b-ene-4a,17-dione 

Relevant academic research and scientific papers

Synthesis of 2,19-Bridged Androstenediones

The syntheses of 2,19-(methyleneoxy)androst-4-ene-3,17-dione (4a), a potent, time-dependent inhibitor of human placental aromatase, and its thio (4b), amino (5), and methylene (14) analogs are descibed.The key step in the construction of 4a, 4b, and 5 is

2β,19-ethylene bridged steroids as aromatase inhibitors

The present invention is directed to a group of androstane compounds which contain an ethylene radical bridging the 2- and 19-positions. These compounds are useful as aromatase inhibitors and they are prepared by the cyclization of a 19-[2-(4-toluenesulfo