1426535-84-3Relevant articles and documents
Siladenoserinols A-L: New sulfonated serinol derivatives from a tunicate as inhibitors of p53-Hdm2 interaction
Nakamura, Yuichi,Kato, Hikaru,Nishikawa, Tadateru,Iwasaki, Noriyuki,Suwa, Yoshiaki,Rotinsulu, Henki,Losung, Fije,Maarisit, Wilmar,Mangindaan, Remy E. P.,Morioka, Hiroshi,Yokosawa, Hideyoshi,Tsukamoto, Sachiko
supporting information, p. 322 - 325 (2013/05/21)
Siladenoserinols A-L were isolated from a tunicate as inhibitors of p53-Hdm2 interaction, a promising target for cancer chemotherapy. Their structures including the absolute configurations were elucidated to be new sulfonated serinol derivatives, each of which contains a 6,8-dioxabicyclo[3.2.1] octane unit and either glycerophosphocholine or glycerophosphoethanolamine moiety. They inhibited p53-Hdm2 interaction with IC50 values of 2.0-55 μM. Among them, siladenoserinol A and B exhibited the strongest inhibition with an IC50 value of 2.0 μM.
