1426537-74-7Relevant academic research and scientific papers
Heteroatom analogues of hydrocodone: Synthesis and biological activity
Giacometti, Robert D.,Duchek, Jan,Werner, Lukas,Husni, Afeef S.,McCurdy, Christopher R.,Cutler, Stephen J.,Phillip Cox,Hudlicky, Tomas
, p. 2914 - 2925 (2013)
Heteroatom analogues of hydrocodone, in which the N-methyl functionality was replaced with oxygen, sulfur, sulfoxide, and sulfone, were prepared by a short sequence from the ethylene glycol ketal of hydrocodone; a carbocyclic analogue of bisnorhydrocodone was also prepared. The compounds were tested for receptor binding and revealed moderate levels of activity for the sulfone analogue of hydrocodone.
